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Lentiviral Protein Transduction with Genome-Modifying HIV-1 Integrase-I-PpoI Fusion Proteins: Studies on Specificity and Cytotoxicity
Rare-cutting endonucleases, such as the I-PpoI, can be used for the induction of double strand breaks (DSBs) in genome editing and targeted integration based on homologous recombination. For therapeutic approaches, the specificity and the pattern of off-target effects are of high importance in these...
Autores principales: | Turkki, Vesa, Schenkwein, Diana, Timonen, Oskari, Husso, Tiia, Lesch, Hanna P., Ylä-Herttuala, Seppo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016911/ https://www.ncbi.nlm.nih.gov/pubmed/24860818 http://dx.doi.org/10.1155/2014/379340 |
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