Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis

SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING protein required for the activity of Cullin-RING ligase (CRL). Our recent study showed that Sag total knockout caused embryonic lethality at E11.5–12.5 days with associated defects in vasculogenesis. Whether Sag is required for...

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Detalles Bibliográficos
Autores principales: Tan, Mingjia, Li, Hua, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016996/
https://www.ncbi.nlm.nih.gov/pubmed/24213570
http://dx.doi.org/10.1038/onc.2013.473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016996/
https://www.ncbi.nlm.nih.gov/pubmed/24213570
http://dx.doi.org/10.1038/onc.2013.473

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