PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling

Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits skin tumorigenesis through mechanisms that may be dependent on HRAS signaling. The present study examined the hypothesis that PPARβ/δ promotes HRAS-induced senescence resulting in suppression of tumorigenesis. PPARβ/δ expression incre...

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Detalles Bibliográficos
Autores principales: Zhu, Bokai, Ferry, Christina H., Blazanin, Nicholas, Bility, Moses T., Khozoie, Combiz, Kang, Boo-Hyon, Glick, Adam B., Gonzalez, Frank J., Peters, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017002/
https://www.ncbi.nlm.nih.gov/pubmed/24213576
http://dx.doi.org/10.1038/onc.2013.477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017002/
https://www.ncbi.nlm.nih.gov/pubmed/24213576
http://dx.doi.org/10.1038/onc.2013.477

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