A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis

BACKGROUND: Fcγ receptors mediate important biological signals in myeloid cells including the ingestion of microorganisms through a process of phagocytosis. It is well-known that Fcγ receptor (FcγR) crosslinking induces the tyrosine phosphorylation of CBL which is associated with FcγR mediated phago...

Descripción completa

Detalles Bibliográficos
Autores principales: Joshi, Shweta, Singh, Alok Ranjan, Zulcic, Muamera, Durden, Donald L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017086/
https://www.ncbi.nlm.nih.gov/pubmed/24886428
http://dx.doi.org/10.1186/1471-2172-15-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017086/
https://www.ncbi.nlm.nih.gov/pubmed/24886428
http://dx.doi.org/10.1186/1471-2172-15-18

Ejemplares similares