Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest, and transcriptional regulation. Here, we report the identification of a...

Descripción completa

Detalles Bibliográficos
Autores principales: Savage, Kienan I., Gorski, Julia J., Barros, Eliana M., Irwin, Gareth W., Manti, Lorenzo, Powell, Alexander J., Pellagatti, Andrea, Lukashchuk, Natalia, McCance, Dennis J., McCluggage, W. Glenn, Schettino, Giuseppe, Salto-Tellez, Manuel, Boultwood, Jacqueline, Richard, Derek J., McDade, Simon S., Harkin, D. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017265/
https://www.ncbi.nlm.nih.gov/pubmed/24746700
http://dx.doi.org/10.1016/j.molcel.2014.03.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017265/
https://www.ncbi.nlm.nih.gov/pubmed/24746700
http://dx.doi.org/10.1016/j.molcel.2014.03.021

Ejemplares similares