Cargando…

Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest, and transcriptional regulation. Here, we report the identification of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Savage, Kienan I., Gorski, Julia J., Barros, Eliana M., Irwin, Gareth W., Manti, Lorenzo, Powell, Alexander J., Pellagatti, Andrea, Lukashchuk, Natalia, McCance, Dennis J., McCluggage, W. Glenn, Schettino, Giuseppe, Salto-Tellez, Manuel, Boultwood, Jacqueline, Richard, Derek J., McDade, Simon S., Harkin, D. Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017265/ https://www.ncbi.nlm.nih.gov/pubmed/24746700 http://dx.doi.org/10.1016/j.molcel.2014.03.021

Ejemplares similares

HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures
por: Pickard, Adam, et al.
Publicado: (2015)

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis
por: Gorski, Julia J., et al.
Publicado: (2011)

p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling
por: Srivastava, Kirtiman, et al.
Publicado: (2015)

NF-κB is a Critical Mediator of BRCA1 induced Chemoresistance
por: Harte, Mary T, et al.
Publicado: (2013)

Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors
por: Lappin, Katrina M., et al.
Publicado: (2022)

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells
por: Cichon, Ann-Christin, et al.
Publicado: (2013)

Towards developing a meaningful grading system for cervical squamous cell carcinoma
por: McCluggage, W Glenn
Publicado: (2018)

Progress in the pathological arena of gynecological cancers
por: McCluggage, W. Glenn
Publicado: (2021)

El esquiador centrado /
por: McCluggage, Denise
Publicado: (1982)

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress
por: McDade, Simon S., et al.
Publicado: (2014)

Letter to the editor, Reply to: Cecile Colpaert et al.: Ultrastaging of sentinel lymph nodes in gynecological cancer: Repeating the story of breast cancer?
por: Cibula, David, et al.
Publicado: (2019)

DNA Cloning 3: Complex genomes: Edited by D.M. Glover and B.D. Hames. Oxford Science, Oxford. ISBN 0-19-963483-1; 0-19-963482-3. Price: £50 (hardback); £25 (paperback)
por: McCance, Dennis J.
Publicado: (1996)

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach
por: Craig, Stephanie G., et al.
Publicado: (2019)

Safety of TNF inhibitors in adolescents and children
por: McCluggage, Lauren Keyser
Publicado: (2010)

Extramedullary gastric plasmacytoma.
por: Hamilton, J. W., et al.
Publicado: (1999)

Primary squamous carcinoma of the thyroid.
por: Jones, J. M., et al.
Publicado: (2000)

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export
por: Vohhodina, Jekaterina, et al.
Publicado: (2017)

The Techniques: middleware developers' golden rules
por: Gavin McCance
Publicado: (2008)

IGF-Binding Protein 2 – Oncogene or Tumor Suppressor?
por: Pickard, Adam, et al.
Publicado: (2015)

Recent Advances in the 5q- Syndrome
por: Pellagatti, Andrea, et al.
Publicado: (2015)

The impact of spliceosome mutations in MDS
por: Boultwood, Jacqueline, et al.
Publicado: (2019)

High EMSY expression defines a BRCA‐like subgroup of high‐grade serous ovarian carcinoma with prolonged survival and hypersensitivity to platinum
por: Hollis, Robert L., et al.
Publicado: (2019)

Chemoprevention in BRCA1 mutation carriers (CIBRAC): protocol for an open allocation crossover feasibility trial assessing mechanisms of chemoprevention with goserelin and anastrozole versus tamoxifen and acceptability of treatment
por: Campbell, Aideen M, et al.
Publicado: (2018)

Endocrine Autoimmunity and Associated Conditions
por: McCance, David R
Publicado: (1999)

Membership Matters
por: McCance, David R.
Publicado: (1998)

The Role of the Developing Kidney in the Maintenance of Internal Stability
por: McCance, R. A.
Publicado: (1972)

WLCG Input to Pisa workshop on Resilience-Explicit Computing in Grids
por: Shiers, J, et al.
Publicado: (2008)

Addressing the potential threat of bioterrorism--value added to an improved public health infrastructure.
por: McDade, J E
Publicado: (1999)

Multifocal breast cancers are more prevalent in BRCA2 versus BRCA1 mutation carriers
por: McCrorie, Alan D, et al.
Publicado: (2020)

The declining autopsy rate and clinicians' attitudes.
por: Loughrey, M. B., et al.
Publicado: (2000)

Survey Results on Pathologic Aspects of Endocervical Adenocarcinoma by the International Society of Gynecological Pathologists
por: McCluggage, W. Glenn, et al.
Publicado: (2021)

miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes()
por: McKenna, Declan J., et al.
Publicado: (2014)

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML
por: Smith, James S., et al.
Publicado: (2020)

Surgical decision making in premenopausal BRCA carriers considering risk-reducing early salpingectomy or salpingo-oophorectomy: a qualitative study
por: Gaba, Faiza, et al.
Publicado: (2022)

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation
por: McDade, Simon S., et al.
Publicado: (2012)

Robust and Resilient Services â How to design, build and operate them
por: Shiers, J, et al.
Publicado: (2007)

p300 Alters Keratinocyte Cell Growth and Differentiation through Regulation of p21(Waf1/CIP1)
por: Wong, Ping-Pui, et al.
Publicado: (2010)

Nutritional and clinical associations of food cravings in pregnancy
por: Hill, A. J., et al.
Publicado: (2015)

Educational supervision of pre-registration house officers.
por: Doherty, C. C., et al.
Publicado: (1992)

Bioterrorism as a public health threat.
por: McDade, J E, et al.
Publicado: (1998)

Cannot write session to /tmp/vufind_sessions/sess_f1a0o1ge6bfnbiocb59o2b761q