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Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure
[Image: see text] Many cellular proteins are ‘disordered’ in isolation. A subset of these intrinsically disordered proteins (IDPs) can, upon binding another molecule, fold to a well-defined three-dimensional structure. In the structurally heterogeneous, unbound ensemble of these IDPs, conformations...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017604/ https://www.ncbi.nlm.nih.gov/pubmed/24654952 http://dx.doi.org/10.1021/ja4125065 |