Bioretrosynthetic construction of a didanosine biosynthetic pathway

Concatenation of engineered biocatalysts into multistep pathways dramatically increases their utility, but development of generalizable assembly methods remains a significant challenge. Herein we evaluate ‘bioretrosynthesis’, which is an application of the retrograde evolution hypothesis, for biosyn...

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Detalles Bibliográficos
Autores principales: Birmingham, William R., Starbird, Chrystal A., Panosian, Timothy D., Nannemann, David P., Iverson, T. M., Bachmann, Brian O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017637/
https://www.ncbi.nlm.nih.gov/pubmed/24657930
http://dx.doi.org/10.1038/nchembio.1494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017637/
https://www.ncbi.nlm.nih.gov/pubmed/24657930
http://dx.doi.org/10.1038/nchembio.1494

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