Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrog...

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Detalles Bibliográficos
Autores principales: Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, GR Scott, Chandel, Navdeep S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017650/
https://www.ncbi.nlm.nih.gov/pubmed/24843020
http://dx.doi.org/10.7554/eLife.02242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017650/
https://www.ncbi.nlm.nih.gov/pubmed/24843020
http://dx.doi.org/10.7554/eLife.02242

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