Cargando…

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wheaton, William W, Weinberg, Samuel E, Hamanaka, Robert B, Soberanes, Saul, Sullivan, Lucas B, Anso, Elena, Glasauer, Andrea, Dufour, Eric, Mutlu, Gokhan M, Budigner, GR Scott, Chandel, Navdeep S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Human Biology and Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017650/ https://www.ncbi.nlm.nih.gov/pubmed/24843020 http://dx.doi.org/10.7554/eLife.02242

Ejemplares similares

Mitochondrial metabolism as a regulator of keratinocyte differentiation
por: Hamanaka, Robert B, et al.
Publicado: (2013)

Metformin Inhibits Mitochondrial Complex I To Promote Health
por: Chandel, Navdeep
Publicado: (2021)

Mitochondrial reactive oxygen species and cancer
por: Sullivan, Lucas B, et al.
Publicado: (2014)

Mitochondrial metabolism in TCA cycle mutant cancer cells
por: Sullivan, Lucas B, et al.
Publicado: (2014)

Metformin, mitochondria and cancer
por: Chandel, Navdeep S
Publicado: (2014)

Targeting glucose metabolism for cancer therapy
por: Hamanaka, Robert B., et al.
Publicado: (2012)

Four key questions about metformin and cancer
por: Chandel, Navdeep
Publicado: (2014)

Alcohol Worsens Acute Lung Injury by Inhibiting Alveolar Sodium Transport through the Adenosine A1 Receptor
por: Dada, Laura, et al.
Publicado: (2012)

Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway
por: Soberanes, Saul, et al.
Publicado: (2012)

Restoration
por: Weinberg, Richard B.
Publicado: (2021)

The mitochondrial respiratory chain is essential for haematopoietic stem cell function
por: Ansó, Elena, et al.
Publicado: (2017)

Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis
por: Diebold, Lauren P., et al.
Publicado: (2019)

Particulate Matter Air Pollution: Effects on the Cardiovascular System
por: Hamanaka, Robert B., et al.
Publicado: (2018)

The Airway Epithelial Response to Air Pollution: It’s Not Just Inflammation
por: Hamanaka, Robert B., et al.
Publicado: (2020)

Our Compliments to the Authors: Decay Accelerating Factor and the Complement System in Pulmonary Fibrosis
por: Hamanaka, Robert B., et al.
Publicado: (2022)

Mitochondrial TCA cycle metabolites control physiology and disease
por: Martínez-Reyes, Inmaculada, et al.
Publicado: (2020)

Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis
por: Romero-Morales, Alejandra I., et al.
Publicado: (2022)

Mitochondrial ubiquinol oxidation is necessary for tumor growth
por: Martínez-Reyes, Inmaculada, et al.
Publicado: (2020)

Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice
por: Mutlu, Ece A, et al.
Publicado: (2011)

Impaired Clearance of Influenza A Virus in Obese, Leptin Receptor Deficient Mice Is Independent of Leptin Signaling in the Lung Epithelium and Macrophages
por: Radigan, Kathryn A., et al.
Publicado: (2014)

Metabolic changes in cancer cells upon suppression of MYC
por: Anso, Elena, et al.
Publicado: (2013)

The Q(o) site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
por: Bell, Eric L., et al.
Publicado: (2007)

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
por: Luengo, Alba, et al.
Publicado: (2014)

Nighttime Encounter
por: Sampson, Samuel
Publicado: (2015)

Reductive carboxylation supports growth in tumor cells with defective mitochondria
por: Mullen, Andrew R., et al.
Publicado: (2011)

Suppression of Superoxide-Hydrogen Peroxide Production at Site I(Q) of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes
por: Piao, Lin, et al.
Publicado: (2020)

Mitochondrial DNA common deletion is not associated with thyroid, breast and colorectal tumors in Turkish patients
por: Aral, Cenk, et al.
Publicado: (2010)

How Can Follow-Up of Patients with Raynaud Phenomenon be Optimized?
por: Kadan, Murat, et al.
Publicado: (2015)

Assessment of human expertise and movement kinematics in first-person shooter games
por: Donovan, Ian, et al.
Publicado: (2022)

From Empathy to Caring: Defining the Ideal Approach to a Healing Relationship
por: Weiner, Saul J., et al.
Publicado: (2008)

Adding Doppler Ultrasonography to the Follow-Up of Patients with Vasospastic Disorder Improves Objectivity
por: Karabacak, Kubilay, et al.
Publicado: (2015)

Mitochondrial COI gene is valid to delimitate Tylenchidae (Nematoda: Tylenchomorpha) species
por: Bai, Mengxin, et al.
Publicado: (2020)

Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function
por: Fu, Zheng, et al.
Publicado: (2019)

Platelet Indices may be Correlated with Severity of Vasospastic Disorders
por: Kadan, Murat, et al.
Publicado: (2015)

Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD(+) balance as a therapeutic strategy
por: Gautam, Mukesh, et al.
Publicado: (2022)

Mitochondria and cancer
por: Chandel, Navdeep S
Publicado: (2014)

Mitochondria as signaling organelles
por: Chandel, Navdeep S
Publicado: (2014)

Mitochondrial metabolism is essential for invariant natural killer T cell development and function
por: Weng, Xiufang, et al.
Publicado: (2021)

MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters
por: Wang, Dongmei, et al.
Publicado: (2023)

Nuclear genes involved in mitochondrial diseases caused by instability of mitochondrial DNA
por: Rusecka, Joanna, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_i0kje7vo40dsp1i6cs3qj4q328