Novel Design Strategy for Checkpoint Kinase 2 Inhibitors Using Pharmacophore Modeling, Combinatorial Fusion, and Virtual Screening

Checkpoint kinase 2 (Chk2) has a great effect on DNA-damage and plays an important role in response to DNA double-strand breaks and related lesions. In this study, we will concentrate on Chk2 and the purpose is to find the potential inhibitors by the pharmacophore hypotheses (PhModels), combinatoria...

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Detalles Bibliográficos
Autores principales: Lin, Chun-Yuan, Wang, Yen-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017722/
https://www.ncbi.nlm.nih.gov/pubmed/24864236
http://dx.doi.org/10.1155/2014/359494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017722/
https://www.ncbi.nlm.nih.gov/pubmed/24864236
http://dx.doi.org/10.1155/2014/359494

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