Simple and Robust Analysis of Cefuroxime in Human Plasma by LC-MS/MS: Application to a Bioequivalence Study

A simple, robust LC-MS/MS assay for quantifying cefuroxime in human plasma was developed. Cefuroxime and tazobactam, as internal standard (IS), were extracted from human plasma by methanol to precipitate protein. Separation was achieved on a Zorbax SB-Aq (4.6 × 250 mm, 5 μm) column under isocratic c...

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Detalles Bibliográficos
Autores principales: Hu, Xingjiang, Huang, Mingzhu, Liu, Jian, Chen, Junchun, Shentu, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017793/
https://www.ncbi.nlm.nih.gov/pubmed/24864138
http://dx.doi.org/10.1155/2014/981624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017793/
https://www.ncbi.nlm.nih.gov/pubmed/24864138
http://dx.doi.org/10.1155/2014/981624

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