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Increased Dapivirine Tissue Accumulation through Vaginal Film Codelivery of Dapivirine and Tenofovir

[Image: see text] The HIV-1 replication inhibitor dapivirine (DPV) is one of the most promising drug candidates being used in topical microbicide products for prevention of HIV-1 sexual transmission. To be able to block HIV-1 replication, DPV must have access to the viral reverse transcriptase enzym...

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Detalles Bibliográficos
Autores principales: Akil, Ayman, Devlin, Brid, Cost, Marilyn, Rohan, Lisa Cencia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018102/
https://www.ncbi.nlm.nih.gov/pubmed/24693866
http://dx.doi.org/10.1021/mp4007024