Solvent-Dependent Divergent Functions of Sc(OTf)(3) in Stereoselective Epoxide-Opening Spiroketalizations

[Image: see text] A stereocontrolled synthesis of benzannulated spiroketals has been developed using solvent-dependent Sc(OTf)(3)-mediated spirocyclizations of exo-glycal epoxides having alcohol side chains. In THF, the reaction proceeds via Lewis acid catalysis under kinetic control with inversion...

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Detalles Bibliográficos
Autores principales: Sharma, Indrajeet, Wurst, Jacqueline M., Tan, Derek S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018158/
https://www.ncbi.nlm.nih.gov/pubmed/24742081
http://dx.doi.org/10.1021/ol500853q

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018158/
https://www.ncbi.nlm.nih.gov/pubmed/24742081
http://dx.doi.org/10.1021/ol500853q

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