Short Term Feeding of a High Fat Diet Exerts an Additive Effect on Hepatocellular Damage and Steatosis in Liver-Specific PTEN Knockout Mice

BACKGROUND: Hepatospecific deletion of PTEN results in constitutive activation of Akt and increased lipogenesis. In mice, the addition of a high fat diet (HFD) downregulates lipogenesis. The aim of this study was to determine the effects of a HFD on hepatocellular damage induced by deletion of PTEN....

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Detalles Bibliográficos
Autores principales: Shearn, Colin T., Mercer, Kelly E., Orlicky, David J., Hennings, Leah, Smathers-McCullough, Rebecca L., Stiles, Bangyan L., Ronis, Martin J. J., Petersen, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018288/
https://www.ncbi.nlm.nih.gov/pubmed/24818992
http://dx.doi.org/10.1371/journal.pone.0096553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018288/
https://www.ncbi.nlm.nih.gov/pubmed/24818992
http://dx.doi.org/10.1371/journal.pone.0096553

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