S1P(1) Receptor Modulation Preserves Vascular Function in Mesenteric and Coronary Arteries after CPB in the Rat Independent of Depletion of Lymphocytes

BACKGROUND: Cardiopulmonary bypass (CPB) may induce systemic inflammation and vascular dysfunction. Sphingosine 1-phosphate (S1P) modulates various vascular and immune responses. Here we explored whether agonists of the S1P receptors, FTY720 and SEW2871 improve vascular reactivity after CPB in the r...

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Detalles Bibliográficos
Autores principales: Samarska, Iryna V., Bouma, Hjalmar R., Buikema, Hendrik, Mungroop, Hubert E., Houwertjes, Martin C., Absalom, Anthony R., Epema, Anne H., Henning, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018292/
https://www.ncbi.nlm.nih.gov/pubmed/24819611
http://dx.doi.org/10.1371/journal.pone.0097196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018292/
https://www.ncbi.nlm.nih.gov/pubmed/24819611
http://dx.doi.org/10.1371/journal.pone.0097196

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