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S1P(1) Receptor Modulation Preserves Vascular Function in Mesenteric and Coronary Arteries after CPB in the Rat Independent of Depletion of Lymphocytes

BACKGROUND: Cardiopulmonary bypass (CPB) may induce systemic inflammation and vascular dysfunction. Sphingosine 1-phosphate (S1P) modulates various vascular and immune responses. Here we explored whether agonists of the S1P receptors, FTY720 and SEW2871 improve vascular reactivity after CPB in the r...

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Detalles Bibliográficos
Autores principales:	Samarska, Iryna V., Bouma, Hjalmar R., Buikema, Hendrik, Mungroop, Hubert E., Houwertjes, Martin C., Absalom, Anthony R., Epema, Anne H., Henning, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018292/ https://www.ncbi.nlm.nih.gov/pubmed/24819611 http://dx.doi.org/10.1371/journal.pone.0097196

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