Important Role of CYP2J2 in Protein Kinase Inhibitor Degradation: A Possible Role in Intratumor Drug Disposition and Resistance

We have investigated in vitro the metabolic capability of 3 extrahepatic cytochromes P-450, CYP1A1, 1B1 and 2J2, known to be over-expressed in various tumors, to biotransform 5 tyrosine kinase inhibitors (TKI): dasatinib, imatinib, nilotinib, sorafenib and sunitinib. Moreover, mRNA expression of CYP...

Descripción completa

Detalles Bibliográficos
Autores principales: Narjoz, Céline, Favre, Amélie, McMullen, Justin, Kiehl, Philippe, Montemurro, Michael, Figg, William D., Beaune, Philippe, de Waziers, Isabelle, Rochat, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018390/
https://www.ncbi.nlm.nih.gov/pubmed/24819355
http://dx.doi.org/10.1371/journal.pone.0095532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018390/
https://www.ncbi.nlm.nih.gov/pubmed/24819355
http://dx.doi.org/10.1371/journal.pone.0095532

Ejemplares similares