Inhibition of hepatic microsomal triglyceride transfer protein – a novel therapeutic option for treatment of homozygous familial hypercholesterolemia

Familial hypercholesterolemia (FH) is an autosomal dominant disease caused by mutations in the low-density lipoprotein (LDL)-receptor gene (LDLR). Patients with homozygous FH (hoFH) have inherited a mutated LDLR gene from both parents, and therefore all their LDL-receptors are incapable of functioni...

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Detalles Bibliográficos
Autores principales: Vuorio, Alpo, Tikkanen, Matti J, Kovanen, Petri T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018418/
https://www.ncbi.nlm.nih.gov/pubmed/24851052
http://dx.doi.org/10.2147/VHRM.S36641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018418/
https://www.ncbi.nlm.nih.gov/pubmed/24851052
http://dx.doi.org/10.2147/VHRM.S36641

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