Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface. We report the crystal structure of a protein complex...

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Detalles Bibliográficos
Autores principales: Jia, Xiaofei, Weber, Erin, Tokarev, Andrey, Lewinski, Mary, Rizk, Maryan, Suarez, Marissa, Guatelli, John, Xiong, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018625/
https://www.ncbi.nlm.nih.gov/pubmed/24843023
http://dx.doi.org/10.7554/eLife.02362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018625/
https://www.ncbi.nlm.nih.gov/pubmed/24843023
http://dx.doi.org/10.7554/eLife.02362

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