Dynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through its phosphorylation by the type 1 casein kinase Yck3

Maturation of organelles in the endolysosomal pathway requires exchange of the early endosomal GTPase Rab5/Vps21 for the late endosomal Rab7/Ypt7. The Rab exchange depends on the guanine nucleotide exchange factor activity of the Mon1-Ccz1 heterodimer for Ypt7. Here we investigate vacuole binding an...

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Detalles Bibliográficos
Autores principales: Lawrence, Gus, Brown, Christopher C., Flood, Blake A., Karunakaran, Surya, Cabrera, Margarita, Nordmann, Mirjana, Ungermann, Christian, Fratti, Rutilio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019492/
https://www.ncbi.nlm.nih.gov/pubmed/24623720
http://dx.doi.org/10.1091/mbc.E13-08-0460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019492/
https://www.ncbi.nlm.nih.gov/pubmed/24623720
http://dx.doi.org/10.1091/mbc.E13-08-0460

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