Impairment of Visual Function and Retinal ER Stress Activation in Wfs1-Deficient Mice

Wolfram syndrome is an early onset genetic disease (1/180,000) featuring diabetes mellitus and optic neuropathy, associated to mutations in the WFS1 gene. Wfs1−/− mouse model shows pancreatic beta cell atrophy, but its visual performance has not been investigated, prompting us to study its visual fu...

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Detalles Bibliográficos
Autores principales: Bonnet Wersinger, Delphine, Benkafadar, Nesrine, Jagodzinska, Jolanta, Hamel, Christian, Tanizawa, Yukio, Lenaers, Guy, Delettre, Cécile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019519/
https://www.ncbi.nlm.nih.gov/pubmed/24823368
http://dx.doi.org/10.1371/journal.pone.0097222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019519/
https://www.ncbi.nlm.nih.gov/pubmed/24823368
http://dx.doi.org/10.1371/journal.pone.0097222

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