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Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins)
Glycosidases are associated with various human diseases. The development of efficient and specific inhibitors may provide powerful tools to modulate their activity. However, achieving high selectivity is a major challenge given that glycosidases with different functions can have similar enzymatic me...
Autores principales: | Correa, Agustín, Pacheco, Sabino, Mechaly, Ariel E., Obal, Gonzalo, Béhar, Ghislaine, Mouratou, Barbara, Oppezzo, Pablo, Alzari, Pedro M., Pecorari, Frédéric |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019568/ https://www.ncbi.nlm.nih.gov/pubmed/24823716 http://dx.doi.org/10.1371/journal.pone.0097438 |
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