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Rational Design of Berberine-Based FtsZ Inhibitors with Broad-Spectrum Antibacterial Activity
Inhibition of the functional activity of Filamenting temperature-sensitive mutant Z (FtsZ) protein, an essential and highly conserved bacterial cytokinesis protein, is a promising approach for the development of a new class of antibacterial agents. Berberine, a benzylisoquinoline alkaloid widely use...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019636/ https://www.ncbi.nlm.nih.gov/pubmed/24824618 http://dx.doi.org/10.1371/journal.pone.0097514 |