Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts

BACKGROUND: Expression of miR-17-92 enhances T-cell survival and interferon (IFN)-γ production. We previously reported that miR-17-92 is down-regulated in T-cells derived from glioblastoma (GBM) patients. We hypothesized that transgene-derived co-expression of miR17-92 and chimeric antigen receptor...

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Detalles Bibliográficos
Autores principales: Ohno, Masasuke, Ohkuri, Takayuki, Kosaka, Akemi, Tanahashi, Kuniaki, June, Carl H, Natsume, Atsushi, Okada, Hideho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019893/
https://www.ncbi.nlm.nih.gov/pubmed/24829757
http://dx.doi.org/10.1186/2051-1426-1-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019893/
https://www.ncbi.nlm.nih.gov/pubmed/24829757
http://dx.doi.org/10.1186/2051-1426-1-21

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