Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment

BACKGROUND: Blockade of immune inhibitory pathways is emerging as an important therapeutic modality for the treatment of cancer. Single agent treatments have partial anti-tumor activity in preclinical models and in human cancer patients. Inasmuch as the tumor microenvironment shows evidence of multi...

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Detalles Bibliográficos
Autores principales: Spranger, Stefani, Koblish, Holly K, Horton, Brendan, Scherle, Peggy A, Newton, Robert, Gajewski, Thomas F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019906/
https://www.ncbi.nlm.nih.gov/pubmed/24829760
http://dx.doi.org/10.1186/2051-1426-2-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019906/
https://www.ncbi.nlm.nih.gov/pubmed/24829760
http://dx.doi.org/10.1186/2051-1426-2-3

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