Mining the mutanome: developing highly personalized Immunotherapies based on mutational analysis of tumors

T cells can mediate remarkable tumor regressions including complete cure in patients with metastatic cancer. Genetic alterations in an individual’s cancer cells (the mutanome) encode unique peptides (m-peptides) that can be targets for T cells. The recent advances in next-generation sequencing and c...

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Detalles Bibliográficos
Autores principales: Overwijk, Willem W, Wang, Ena, Marincola, Francesco M, Rammensee, Hans-Georg, Restifo, Nicholas P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019909/
https://www.ncbi.nlm.nih.gov/pubmed/24829748
http://dx.doi.org/10.1186/2051-1426-1-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019909/
https://www.ncbi.nlm.nih.gov/pubmed/24829748
http://dx.doi.org/10.1186/2051-1426-1-11

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