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Mining the mutanome: developing highly personalized Immunotherapies based on mutational analysis of tumors
T cells can mediate remarkable tumor regressions including complete cure in patients with metastatic cancer. Genetic alterations in an individual’s cancer cells (the mutanome) encode unique peptides (m-peptides) that can be targets for T cells. The recent advances in next-generation sequencing and c...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019909/ https://www.ncbi.nlm.nih.gov/pubmed/24829748 http://dx.doi.org/10.1186/2051-1426-1-11 |