A 3′UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1

BACKGROUND: The Polo-like Kinase 1 (PLK1) protein regulates cell cycle progression and is overexpressed in many malignant tissues. Overexpression is associated with poor prognosis in several cancer entities, whereby expression of PLK1 shows high inter-individual variability. Although PLK1 is extensi...

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Detalles Bibliográficos
Autores principales: Akdeli, Neval, Riemann, Kathrin, Westphal, Jana, Hess, Jochen, Siffert, Winfried, Bachmann, Hagen S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020576/
https://www.ncbi.nlm.nih.gov/pubmed/24767679
http://dx.doi.org/10.1186/1476-4598-13-87

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020576/
https://www.ncbi.nlm.nih.gov/pubmed/24767679
http://dx.doi.org/10.1186/1476-4598-13-87

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