Expression of wild‐type and mutant S20G hIAPP in physiologic knock‐in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

Aims/Introduction:  Human islet polypeptide S20G mutation (hIAPP(S20G)) is associated with earlier onset type 2 diabetes and increased amyloidogenicity and cytotoxicity in vitro vs wild‐type hIAPP (hIAPP(WT)), suggesting that amyloidogenesis may be pathogenic for type 2 diabetes. We compared the con...

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Detalles Bibliográficos
Autores principales: Hiddinga, Henry J, Sakagashira, Setsuya, Ishigame, Masayuki, Madde, Pranathi, Sanke, Tokio, Nanjo, Kishio, Kudva, Yogish C, Lee, James J, van Deursen, Jan, Eberhardt, Norman L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020731/
https://www.ncbi.nlm.nih.gov/pubmed/24843557
http://dx.doi.org/10.1111/j.2040-1124.2011.00166.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020731/
https://www.ncbi.nlm.nih.gov/pubmed/24843557
http://dx.doi.org/10.1111/j.2040-1124.2011.00166.x

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