Activation and allosteric modulation of a muscarinic acetylcholine receptor

Despite recent advances in crystallography of G protein-coupled receptors (GPCRs), little is known about the mechanism of their activation process, as only the β(2) adrenergic receptor (β(2)AR) and rhodopsin have been crystallized in fully active conformations. Here, we report the structure of an ag...

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Detalles Bibliográficos
Autores principales: Kruse, Andrew C., Ring, Aaron M., Manglik, Aashish, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Hübner, Harald, Pardon, Els, Valant, Celine, Sexton, Patrick M., Christopoulos, Arthur, Felder, Christian C., Gmeiner, Peter, Steyaert, Jan, Weis, William I., Garcia, K. Christopher, Wess, Jürgen, Kobilka, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020789/
https://www.ncbi.nlm.nih.gov/pubmed/24256733
http://dx.doi.org/10.1038/nature12735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020789/
https://www.ncbi.nlm.nih.gov/pubmed/24256733
http://dx.doi.org/10.1038/nature12735

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