Cargando…

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Despite recent advances in crystallography of G protein-coupled receptors (GPCRs), little is known about the mechanism of their activation process, as only the β(2) adrenergic receptor (β(2)AR) and rhodopsin have been crystallized in fully active conformations. Here, we report the structure of an ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kruse, Andrew C., Ring, Aaron M., Manglik, Aashish, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Hübner, Harald, Pardon, Els, Valant, Celine, Sexton, Patrick M., Christopoulos, Arthur, Felder, Christian C., Gmeiner, Peter, Steyaert, Jan, Weis, William I., Garcia, K. Christopher, Wess, Jürgen, Kobilka, Brian K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020789/ https://www.ncbi.nlm.nih.gov/pubmed/24256733 http://dx.doi.org/10.1038/nature12735

Ejemplares similares

Allosteric Modulation of Muscarinic Acetylcholine Receptors
por: Gregory, Karen J, et al.
Publicado: (2007)

Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor
por: Xu, Jun, et al.
Publicado: (2023)

Structure-based discovery of selective positive allosteric modulators of antagonists for the M(2) muscarinic acetylcholine receptor
por: Korczynska, Magdalena, et al.
Publicado: (2018)

Structure and Dynamics of the M(3) Muscarinic Acetylcholine Receptor
por: Kruse, Andrew C., et al.
Publicado: (2012)

Probing the binding site of novel selective positive allosteric modulators at the M(1) muscarinic acetylcholine receptor
por: Khajehali, Elham, et al.
Publicado: (2018)

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs
por: Hollingsworth, Scott A., et al.
Publicado: (2019)

Allosteric Modulation of Muscarinic Acetylcholine Receptors
por: Jakubík, Jan, et al.
Publicado: (2010)

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias
por: van der Westhuizen, Emma T., et al.
Publicado: (2021)

Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation
por: Staus, Dean P, et al.
Publicado: (2016)

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
por: Liu, Hongtao, et al.
Publicado: (2018)

Structure of the human M(2) muscarinic acetylcholine receptor bound to an antagonist
por: Haga, Kazuko, et al.
Publicado: (2012)

Crystal structure of the M(5) muscarinic acetylcholine receptor
por: Vuckovic, Ziva, et al.
Publicado: (2019)

Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors
por: Burger, Wessel A.C., et al.
Publicado: (2018)

Applications of molecular replacement to G protein-coupled receptors
por: Kruse, Andrew C., et al.
Publicado: (2013)

Allosteric coupling from G protein to the agonist binding pocket in GPCRs
por: DeVree, Brian T., et al.
Publicado: (2016)

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
por: Bradley, Sophie J., et al.
Publicado: (2016)

Adrenaline-activated structure of the β(2)-adrenoceptor stabilized by an engineered nanobody
por: Ring, Aaron M., et al.
Publicado: (2013)

Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M(2)R Affinity and Selectivity
por: She, Xueke, et al.
Publicado: (2017)

Structure of the δ-opioid receptor bound to naltrindole
por: Granier, Sébastien, et al.
Publicado: (2012)

Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory
por: Leaderbrand, Katherine, et al.
Publicado: (2016)

FRET-Based Detection of M(1) Muscarinic Acetylcholine Receptor Activation by Orthosteric and Allosteric Agonists
por: Markovic, Danijela, et al.
Publicado: (2012)

Bitopic Binding Mode of an M(1) Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
por: Bradley, Sophie J., et al.
Publicado: (2018)

Hepatic Muscarinic Acetylcholine Receptors Are Not Critically Involved in Maintaining Glucose Homeostasis in Mice
por: Li, Jian H., et al.
Publicado: (2009)

Molecular properties of muscarinic acetylcholine receptors
por: HAGA, Tatsuya
Publicado: (2013)

Evolution of the Muscarinic Acetylcholine Receptors in Vertebrates
por: Pedersen, Julia E., et al.
Publicado: (2018)

The M(1) muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice
por: Laspas, Panagiotis, et al.
Publicado: (2019)

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
por: Manglik, Aashish, et al.
Publicado: (2012)

Role of Muscarinic Acetylcholine Signaling in Gastrointestinal Cancers
por: Konishi, Mitsuru, et al.
Publicado: (2019)

Muscarinic Acetylcholine Receptors in the Retina—Therapeutic Implications
por: Ruan, Yue, et al.
Publicado: (2021)

Antipsychotic-Like Effect of the Muscarinic Acetylcholine Receptor Agonist BuTAC in Non-Human Primates
por: Andersen, Maibritt B., et al.
Publicado: (2015)

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus
por: Dennis, Siobhan H., et al.
Publicado: (2016)

Current Advances in Allosteric Modulation of Muscarinic Receptors
por: Jakubik, Jan, et al.
Publicado: (2020)

Structure–activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M(4)
por: Haider, Ahmed, et al.
Publicado: (2023)

Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in Chronic Tinnitus
por: Bojić, Tijana, et al.
Publicado: (2017)

Modeling the allosteric modulation on a G-Protein Coupled Receptor: the case of M2 muscarinic Acetylcholine Receptor in complex with LY211960
por: Maggi, L., et al.
Publicado: (2020)

Characterization of muscarinic acetylcholine receptors in the avian salt gland
Publicado: (1981)

Subtype Differences in Pre-Coupling of Muscarinic Acetylcholine Receptors
por: Jakubík, Jan, et al.
Publicado: (2011)

Dualsteric modulators of the M2 muscarinic acetylcholine receptor
por: Bermudez, Marcel, et al.
Publicado: (2014)

Revisiting the Endocytosis of the M(2) Muscarinic Acetylcholine Receptor
por: Ockenga, Wymke, et al.
Publicado: (2015)

Update on PET Tracer Development for Muscarinic Acetylcholine Receptors
por: Ozenil, Marius, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mic4jubcf5tf1pf4gd6pbe83oa