Identification of the Genomic Insertion Site of Pmel-1 TCR α and β Transgenes by Next-Generation Sequencing

The pmel-1 T cell receptor transgenic mouse has been extensively employed as an ideal model system to study the mechanisms of tumor immunology, CD8(+) T cell differentiation, autoimmunity and adoptive immunotherapy. The ‘zygosity’ of the transgene affects the transgene expression levels and may comp...

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Detalles Bibliográficos
Autores principales: Ji, Yun, Abrams, Natalie, Zhu, Wei, Salinas, Eddie, Yu, Zhiya, Palmer, Douglas C., Jailwala, Parthav, Franco, Zulmarie, Roychoudhuri, Rahul, Stahlberg, Eric, Gattinoni, Luca, Restifo, Nicholas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020793/
https://www.ncbi.nlm.nih.gov/pubmed/24827921
http://dx.doi.org/10.1371/journal.pone.0096650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020793/
https://www.ncbi.nlm.nih.gov/pubmed/24827921
http://dx.doi.org/10.1371/journal.pone.0096650

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