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Orexin A Inhibits Propofol-Induced Neurite Retraction by a Phospholipase D/Protein Kinase C(ε)-Dependent Mechanism in Neurons

BACKGROUND: The intravenous anaesthetic propofol retracts neurites and reverses the transport of vesicles in rat cortical neurons. Orexin A (OA) is an endogenous neuropeptide regulating wakefulness and may counterbalance anaesthesia. We aim to investigate if OA interacts with anaesthetics by inhibit...

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Detalles Bibliográficos
Autores principales: Björnström, Karin, Turina, Dean, Strid, Tobias, Sundqvist, Tommy, Eintrei, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020800/
https://www.ncbi.nlm.nih.gov/pubmed/24828410
http://dx.doi.org/10.1371/journal.pone.0097129