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Deep Intronic Mutation and Pseudo Exon Activation as a Novel Muscular Hypertrophy Modifier in Cattle
Myostatin is essential for proper regulation of myogenesis, and inactivation of Myostatin results in muscle hypertrophy. Here, we identified an unexpected mutation in the myostatin gene which is almost fixed in Blonde d'Aquitaine cattle. In skeletal muscle, the mutant allele was highly expresse...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020855/ https://www.ncbi.nlm.nih.gov/pubmed/24827585 http://dx.doi.org/10.1371/journal.pone.0097399 |