Cargando…

Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones)

BACKGROUND: Oesophageal squamous cell carcinoma (OSCC) is a highly aggressive carcinoma with a poor survival rate. One of the most commonly used chemotherapeutic drugs, cisplatin, displays varied and often poor efficacy in vivo. Therefore, alternative, cost-effective and more efficacious treatments...

Descripción completa

Detalles Bibliográficos
Autores principales:	Damelin, Leonard Howard, Jivan, Rupal, Veale, Robin Bruce, Rousseau, Amanda Louise, Mavri-Damelin, Demetra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020916/ https://www.ncbi.nlm.nih.gov/pubmed/24886082 http://dx.doi.org/10.1186/1471-2407-14-314

Ejemplares similares

The decatenation checkpoint
por: Damelin, M, et al.
Publicado: (2007)

Photoactivatable bis(thiosemicarbazone) derivatives for copper-64 radiotracer synthesis
por: Earley, Daniel F., et al.
Publicado: (2022)

Promoting computational thinking through project-based learning
por: Shin, Namsoo, et al.
Publicado: (2021)

Copper bis(thiosemicarbazone) complexes modulate P‐glycoprotein expression and function in human brain microvascular endothelial cells
por: Pyun, Jae, et al.
Publicado: (2022)

Factors that determine thione(thiol)–disulfide interconversion in a bis(thiosemicarbazone) copper(ii) complex
por: Jeong, Haewon, et al.
Publicado: (2019)

Liposomal formulations of anticancer copper(ii) thiosemicarbazone complexes
por: Mathuber, Marlene, et al.
Publicado: (2021)

Upregulation of RNA Processing Factors in Poorly Differentiated Lung Cancer Cells
por: Geles, Kenneth G., et al.
Publicado: (2016)

Human serum albumin as a copper source for anticancer thiosemicarbazones
por: Schaier, Martin, et al.
Publicado: (2023)

Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux
por: Bormio Nunes, Julia H., et al.
Publicado: (2020)

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity
por: Karlsson, Henning, et al.
Publicado: (2017)

Preparation, structure elucidation, and antioxidant activity of new bis(thiosemicarbazone) derivatives
por: YAKAN, Hasan
Publicado: (2020)

Thinking in Terms of Change over Time: Opportunities and Challenges of Using System Dynamics Models
por: Eidin, Emil, et al.
Publicado: (2023)

Characterisation of an Isogenic Model of Cisplatin Resistance in Oesophageal Adenocarcinoma Cells
por: Buckley, Amy M., et al.
Publicado: (2019)

Bis(ethanol-κO)bis(pyridine-3-carbaldehyde-κN thiosemicarbazone)bis(thiocyanato-κN)iron(II)–pyridine-3-carbaldehyde thiosemicarbazone (1/2)
por: Wang, Shao-Mei
Publicado: (2009)

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone–Pyridylhydrazone Copper(II) Complex
por: Choo, Xin Yi, et al.
Publicado: (2022)

In vitroreactivation of latent HIV-1 by cytostatic bis(thiosemicarbazonate) gold(III) complexes
por: Fonteh, Pascaline, et al.
Publicado: (2014)

Bis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors
por: Rasool, Asif, et al.
Publicado: (2022)

Thiosemicarbazone scaffold for the design of antifungal and antiaflatoxigenic agents: evaluation of ligands and related copper complexes
por: Rogolino, Dominga, et al.
Publicado: (2017)

Bis(pyridine-2-carbaldehyde thiosemicarbazone)zinc(II) dinitrate dihydrate
por: Cheng, Lin, et al.
Publicado: (2010)

Benzaldehyde thiosemicarbazone
por: Kong, Lingqian, et al.
Publicado: (2008)

Knockdown of LRP/LR Induces Apoptosis in Breast and Oesophageal Cancer Cells
por: Khumalo, Thandokuhle, et al.
Publicado: (2015)

Downregulation of intracellular nm23-H1 prevents cisplatin-induced DNA damage in oesophageal cancer cells: possible association with Na(+), K(+)-ATPase
por: lizuka, N, et al.
Publicado: (2000)

Benzaldehyde Thiosemicarbazone Derived from Limonene Complexed with Copper Induced Mitochondrial Dysfunction in Leishmania amazonensis
por: Britta, Elizandra Aparecida, et al.
Publicado: (2012)

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters
por: Milunović, Miljan N. M., et al.
Publicado: (2020)

Binding Models of Copper(II) Thiosemicarbazone Complexes with Human Serum Albumin: A Speciation Study
por: May, Nóra V., et al.
Publicado: (2021)

Preparation and Biodistribution Studies of a Radiogallium-Acetylacetonate Bis (Thiosemicarbazone) Complex in Tumor-Bearing Rodents
por: Jalilian, Amir Reza, et al.
Publicado: (2012)

Redistribution of β-catenin in response to EGF and lithium signalling in human oesophageal squamous carcinoma cell lines
por: Jones, Lindsay JG, et al.
Publicado: (2003)

Protection from Intracellular Oxidative Stress by Cytoglobin in Normal and Cancerous Oesophageal Cells
por: McRonald, Fiona E., et al.
Publicado: (2012)

Benzaldehyde thiosemicarbazone monohydrate
por: Gu, Sheng-Jiu, et al.
Publicado: (2008)

Copper(II) Thiosemicarbazone Complexes and Their Proligands upon UVA Irradiation: An EPR and Spectrophotometric Steady-State Study
por: Hricovíni, Michal, et al.
Publicado: (2018)

Pyridine-Based NNS Tridentate Chitosan Thiosemicarbazones and Their Copper(II) Complexes: Synthesis, Characterization, and Anticancer Activity
por: Adhikari, Hari Sharan, et al.
Publicado: (2022)

Introducing N‐Heteroaromatic Bases into Copper(II) Thiosemicarbazon Complexes: A Way to Change their Biological Activity
por: Ulchina, Ianina, et al.
Publicado: (2022)

Evaluation of Antagonistic Effects of Metformin with Cisplatin in Gastric Cancer Cells
por: Lesan, Vahid, et al.
Publicado: (2014)

Cisplatin and etoposide in oesophageal cancer: a phase II study. Rotterdam Oesophageal Tumour Study Group.
por: Kok, T. C., et al.
Publicado: (1996)

Modulation of integrin-linked kinase (ILK) expression in human oesophageal squamous cell carcinoma cell lines by the EGF and TGFβ1 growth factors
por: Driver, Glenn A, et al.
Publicado: (2006)

New Water-Soluble Copper(II) Complexes with Morpholine–Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action
por: Ohui, Kateryna, et al.
Publicado: (2018)

Metformin enhances the radiosensitizing effect of cisplatin in non-small cell lung cancer cell lines with different cisplatin sensitivities
por: Riaz, Muhammad Assad, et al.
Publicado: (2019)

Metformin enhances the chemosensitivity of hepatocarcinoma cells to cisplatin through AMPK pathway
por: Dong, Hao, et al.
Publicado: (2017)

Effects of Cisplatin Combined with Metformin on Proliferation and Apoptosis of Nasopharyngeal Carcinoma Cells
por: Shi, Ling, et al.
Publicado: (2022)

(E)-4-Octyloxybenzaldehyde thiosemicarbazone
por: Islam, M. A. A. A. A., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_q9a79up9nhmiphvaa3hpao0d8b