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Homeostatic Maintenance of Allele-Specific p16 Methylation in Cancer Cells Accompanied by Dynamic Focal Methylation and Hydroxymethylation
AIM: p16 Methylation frequently occurs in carcinogenesis. While it has been hypothesized that the p16 methylation states are dynamically maintained in cancer cells, direct evidence supporting this hypothesis has not been available until now. METHODS: A fusion cell model was established which reprogr...
Autores principales: | Qin, Sisi, Li, Qiang, Zhou, Jing, Liu, Zhao-jun, Su, Na, Wilson, James, Lu, Zhe-ming, Deng, Dajun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020935/ https://www.ncbi.nlm.nih.gov/pubmed/24828678 http://dx.doi.org/10.1371/journal.pone.0097785 |
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