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Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticity

The leading hypothesis on Alzheimer Disease (AD) is that it is caused by buildup of the peptide amyloid-β (Aβ), which initially causes dysregulation of synaptic plasticity and eventually causes destruction of synapses and neurons. Pharmacological efforts to limit Aβ buildup have proven ineffective,...

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Detalles Bibliográficos
Autor principal: Anastasio, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021136/
https://www.ncbi.nlm.nih.gov/pubmed/24847263
http://dx.doi.org/10.3389/fphar.2014.00085