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Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticity
The leading hypothesis on Alzheimer Disease (AD) is that it is caused by buildup of the peptide amyloid-β (Aβ), which initially causes dysregulation of synaptic plasticity and eventually causes destruction of synapses and neurons. Pharmacological efforts to limit Aβ buildup have proven ineffective,...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021136/ https://www.ncbi.nlm.nih.gov/pubmed/24847263 http://dx.doi.org/10.3389/fphar.2014.00085 |