Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice

BACKGROUND: Data from in vivo and in vitro studies suggest that activation of Akt regulates cell survival signaling and plays a key role in tumorigenesis. Hence, transgenic mice were created to explore the oncogenic role of Akt1 in the development of mammary tumors. METHODS: The transgenic mice were...

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Detalles Bibliográficos
Autores principales: Wu, Yanyuan, Kim, Juri, Elshimali, Yayha, Sarkissyan, Marianna, Vadgama, Jaydutt V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021211/
https://www.ncbi.nlm.nih.gov/pubmed/24742286
http://dx.doi.org/10.1186/1471-2407-14-266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021211/
https://www.ncbi.nlm.nih.gov/pubmed/24742286
http://dx.doi.org/10.1186/1471-2407-14-266

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