Left ventricular torsional mechanics and myocardial iron load in beta-thalassaemia major: a potential role of titin degradation

BACKGROUND: Iron may damage sarcomeric proteins through oxidative stress. We explored the left ventricular (LV) torsional mechanics in patients with beta-thalassaemia major and its relationship to myocardial iron load. Using HL-1 cell and B6D2F1 mouse models, we further determined the impact of iron...

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Detalles Bibliográficos
Autores principales: Chen, Mei-pian, Li, Shu-na, Lam, Wendy WM, Ho, Yuen-chi, Ha, Shau-yin, Chan, Godfrey CF, Cheung, Yiu-fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021258/
https://www.ncbi.nlm.nih.gov/pubmed/24725620
http://dx.doi.org/10.1186/1471-2261-14-49

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021258/
https://www.ncbi.nlm.nih.gov/pubmed/24725620
http://dx.doi.org/10.1186/1471-2261-14-49

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