Cargando…

Left ventricular torsional mechanics and myocardial iron load in beta-thalassaemia major: a potential role of titin degradation

BACKGROUND: Iron may damage sarcomeric proteins through oxidative stress. We explored the left ventricular (LV) torsional mechanics in patients with beta-thalassaemia major and its relationship to myocardial iron load. Using HL-1 cell and B6D2F1 mouse models, we further determined the impact of iron...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Mei-pian, Li, Shu-na, Lam, Wendy WM, Ho, Yuen-chi, Ha, Shau-yin, Chan, Godfrey CF, Cheung, Yiu-fai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021258/ https://www.ncbi.nlm.nih.gov/pubmed/24725620 http://dx.doi.org/10.1186/1471-2261-14-49

Ejemplares similares

Dynamic Dyssynchrony and Impaired Contractile Reserve of the Left Ventricle in Beta-Thalassaemia Major: An Exercise Echocardiographic Study
por: Cheung, Yiu-fai, et al.
Publicado: (2012)

Circulating CD133(+)VEGFR2(+) and CD34(+)VEGFR2(+) cells and arterial function in patients with beta-thalassaemia major
por: Cheung, Yiu-fai, et al.
Publicado: (2011)

Native cardiac magnetic resonance T1 mapping and cardiac mechanics as assessed by speckle tracking echocardiography in patients with beta-thalassaemia major()
por: See, Wing-Shan, et al.
Publicado: (2021)

Screening for beta thalassaemia
por: Petrou, Mary
Publicado: (2010)

Iron Overload and Apoptosis of HL-1 Cardiomyocytes: Effects of Calcium Channel Blockade
por: Chen, Mei-pian, et al.
Publicado: (2014)

Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism
por: Vidal, Angela, et al.
Publicado: (2022)

Epistasis and the sensitivity of phenotypic screens for beta thalassaemia
por: Penman, Bridget, et al.
Publicado: (2014)

Epistasis and the sensitivity of phenotypic screens for beta thalassaemia
por: Penman, Bridget S, et al.
Publicado: (2015)

Beta-Thalassaemia Intermedia: Evaluation of Endocrine and Bone Complications
por: Baldini, M., et al.
Publicado: (2014)

Hypochromic Anaemias Not Due to Iron Deficiency: Thalassaemia and Sideroblastic Anaemia
por: Weatherall, D. J.
Publicado: (1969)

α-thalassaemia
por: Harteveld, Cornelis L, et al.
Publicado: (2010)

A Java-based Electronic Healthcare Record Software for Beta-thalassaemia
por: Deftereos, S, et al.
Publicado: (2001)

Hb E/beta-thalassaemia: a common & clinically diverse disorder
por: Olivieri, Nancy F., et al.
Publicado: (2011)

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis
por: Roussos, Petros, et al.
Publicado: (2021)

Beta‐thalassaemia major: Prevalence, risk factors and clinical consequences of hypercalciuria
por: Aliberti, Ludovica, et al.
Publicado: (2022)

Myocardial infarction in patients with severe beta thalassaemia: a case series
por: Premawardhena, Anuja, et al.
Publicado: (2023)

Flight of the titins
por: Dove, Alan W.
Publicado: (2001)

Clash of the titin
por: LeBrasseur, Nicole
Publicado: (2002)

MRI evaluation of tissue iron burden in patients with β-thalassaemia major
por: Argyropoulou, Maria I., et al.
Publicado: (2007)

Effects of combined deferiprone with deferoxamine on right ventricular function in thalassaemia major
por: Alpendurada, Francisco, et al.
Publicado: (2012)

Linagliptin prevents left ventricular stiffening by reducing titin cleavage and hypophosphorylation
por: Cuijpers, Ilona, et al.
Publicado: (2020)

Differential myocardial fibrosis of the systemic right ventricle and subpulmonary left ventricle after atrial switch operation for complete transposition of the great arteries()
por: Cheung, Yiu-fai, et al.
Publicado: (2020)

The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion
por: Introini, Viola, et al.
Publicado: (2022)

Burden of ocular abnormalities in patients with beta thalassaemia: a cross-sectional study
por: Baig, Rashid, et al.
Publicado: (2023)

Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major
por: Baksi, A. John, et al.
Publicado: (2014)

The History of Deferiprone (L1) and the Paradigm of the Complete Treatment of Iron Overload in Thalassaemia
por: Kontoghiorghes, George J., et al.
Publicado: (2020)

Thalassaemia Intermedia: an Update
por: Taher, Ali T., et al.
Publicado: (2009)

A titinic extension
por: Wells, William A.
Publicado: (2002)

Of cilia, titin, and neurosteroids
por: Adler, Elizabeth M.
Publicado: (2014)

Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with β-thalassaemia: the ESCALATOR study
por: Taher, Ali, et al.
Publicado: (2009)

Evaluation of carotid artery dynamics & correlation with cardiac & hepatic iron in β-thalassaemia patients
por: Merchant, Rashid H., et al.
Publicado: (2016)

Deferiprone, an iron chelator, alleviates platelet hyperactivity in patients with β-thalassaemia/HbE
por: Tran, Ngan Thi, et al.
Publicado: (2022)

Troponin and Titin Coordinately Regulate Length-dependent Activation in Skinned Porcine Ventricular Muscle
por: Terui, Takako, et al.
Publicado: (2008)

Thalassaemia and Aberrations of Growth and Puberty
por: Kyriakou, Andreas, et al.
Publicado: (2009)

THALASSAEMIA IS A TROPICAL DISEASE
por: Kotila, T.R.
Publicado: (2012)

A new spring for titin
por: Brunello, Elisabetta, et al.
Publicado: (2020)

The Mechanical Power of Titin Folding
por: Eckels, Edward C., et al.
Publicado: (2019)

Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry
por: Mohd Ibrahim, Hishamshah, et al.
Publicado: (2020)

Myocardial Integrated Backscatter in Obese Adolescents: Associations with Measures of Adiposity and Left Ventricular Deformation
por: Xie, Lijian, et al.
Publicado: (2015)

Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner
por: Fukuda, Norio, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_a2kuh66j95h7uk06n8alk8020u