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Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1

BACKGROUND: We have previously shown that transforming growth factor-beta (TGF-beta) impairs glucocorticoid (GC) function in pulmonary epithelial cell-lines. However, the signalling cascade leading to this impairment is unknown. In the present study, we provide the first evidence that TGF-beta impai...

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Detalles Bibliográficos
Autores principales: Keenan, Christine R, Mok, Josephine SL, Harris, Trudi, Xia, Yuxiu, Salem, Saad, Stewart, Alastair G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021546/
https://www.ncbi.nlm.nih.gov/pubmed/24886104
http://dx.doi.org/10.1186/1465-9921-15-55