Selective Small Molecule Compounds Increase BMP-2 Responsiveness by Inhibiting Smurf1-mediated Smad1/5 Degradation

The ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) negatively regulates bone morphogenetic protein (BMP) pathway by ubiquitinating certain signal components for degradation. Thus, it can be an eligible pharmacological target for increasing BMP signal responsiveness. We established...

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Detalles Bibliográficos
Autores principales: Cao, Yu, Wang, Cheng, Zhang, Xueli, Xing, Guichun, Lu, Kefeng, Gu, Yongqing, He, Fuchu, Zhang, Lingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021816/
https://www.ncbi.nlm.nih.gov/pubmed/24828823
http://dx.doi.org/10.1038/srep04965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021816/
https://www.ncbi.nlm.nih.gov/pubmed/24828823
http://dx.doi.org/10.1038/srep04965

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