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Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity

The molecular mechanisms that mediate genetic variability in response to alcohol are unclear. We find that alcohol has opposite actions (enhancement or suppression) on GABA(A) receptor (GABA(A)R) inhibition in granule cells (GCs) of the cerebellum from behaviorally sensitive, low-alcohol consuming S...

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Detalles Bibliográficos
Autores principales: Kaplan, Joshua S, Mohr, Claudia, Rossi, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022289/
https://www.ncbi.nlm.nih.gov/pubmed/24162656
http://dx.doi.org/10.1038/nn.3559