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NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis
BACKGROUND: A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022329/ https://www.ncbi.nlm.nih.gov/pubmed/24755231 http://dx.doi.org/10.1186/1471-2377-14-87 |
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author | Agúndez, José A G García-Martín, Elena Martínez, Carmen Benito-León, Julián Millán-Pascual, Jorge Calleja, Patricia Díaz-Sánchez, María Pisa, Diana Turpín-Fenoll, Laura Alonso-Navarro, Hortensia Ayuso-Peralta, Lucía Torrecillas, Dolores Plaza-Nieto, José Francisco Jiménez-Jiménez, Félix Javier |
author_facet | Agúndez, José A G García-Martín, Elena Martínez, Carmen Benito-León, Julián Millán-Pascual, Jorge Calleja, Patricia Díaz-Sánchez, María Pisa, Diana Turpín-Fenoll, Laura Alonso-Navarro, Hortensia Ayuso-Peralta, Lucía Torrecillas, Dolores Plaza-Nieto, José Francisco Jiménez-Jiménez, Félix Javier |
author_sort | Agúndez, José A G |
collection | PubMed |
description | BACKGROUND: A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population. METHODS: We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays. RESULTS: NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS. CONCLUSIONS: Our results indicate that NQO1 rs1800566 does not have an effect on MS disease risk. |
format | Online Article Text |
id | pubmed-4022329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40223292014-05-16 NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis Agúndez, José A G García-Martín, Elena Martínez, Carmen Benito-León, Julián Millán-Pascual, Jorge Calleja, Patricia Díaz-Sánchez, María Pisa, Diana Turpín-Fenoll, Laura Alonso-Navarro, Hortensia Ayuso-Peralta, Lucía Torrecillas, Dolores Plaza-Nieto, José Francisco Jiménez-Jiménez, Félix Javier BMC Neurol Research Article BACKGROUND: A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population. METHODS: We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays. RESULTS: NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS. CONCLUSIONS: Our results indicate that NQO1 rs1800566 does not have an effect on MS disease risk. BioMed Central 2014-04-23 /pmc/articles/PMC4022329/ /pubmed/24755231 http://dx.doi.org/10.1186/1471-2377-14-87 Text en Copyright © 2014 Agúndez et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Agúndez, José A G García-Martín, Elena Martínez, Carmen Benito-León, Julián Millán-Pascual, Jorge Calleja, Patricia Díaz-Sánchez, María Pisa, Diana Turpín-Fenoll, Laura Alonso-Navarro, Hortensia Ayuso-Peralta, Lucía Torrecillas, Dolores Plaza-Nieto, José Francisco Jiménez-Jiménez, Félix Javier NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis |
title | NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis |
title_full | NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis |
title_fullStr | NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis |
title_full_unstemmed | NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis |
title_short | NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis |
title_sort | nqo1 gene rs1800566 variant is not associated with risk for multiple sclerosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022329/ https://www.ncbi.nlm.nih.gov/pubmed/24755231 http://dx.doi.org/10.1186/1471-2377-14-87 |
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