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Up-regulation of heme oxygenase-1 after infarct initiation reduces mortality, infarct size and left ventricular remodeling: experimental evidence and proof of concept

BACKGROUND: Up-regulation of HO-1 by genetic manipulation or pharmacological pre-treatment has been reported to provide benefits in several animal models of myocardial infarction (MI). However, its efficacy following MI initiation (as in clinical reality) remains to be tested. Therefore, this study...

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Detalles Bibliográficos
Autores principales: Kusmic, Claudia, Barsanti, Cristina, Matteucci, Marco, Vesentini, Nicoletta, Pelosi, Gualtiero, Abraham, Nader G, L’Abbate, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022338/
https://www.ncbi.nlm.nih.gov/pubmed/24708733
http://dx.doi.org/10.1186/1479-5876-12-89