Synthesis and activity of three new trinuclear platinums with cis-geometry for terminal metal centres

BACKGROUND: As compared to cisplatin, trinuclear platinum compounds such as BBR3464 and DH6Cl have an altered spectrum of activity possibly because they form long-range adducts with DNA as against mainly intrastrand 1,2-bifunctional adducts formed by cisplatin and its analogues. Because of the labil...

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Detalles Bibliográficos
Autores principales: Hamad, Shahnaz A, Beale, Philip, Yu, Jun Q, Huq, Fazlul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022405/
https://www.ncbi.nlm.nih.gov/pubmed/24884683
http://dx.doi.org/10.1186/1423-0127-21-41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022405/
https://www.ncbi.nlm.nih.gov/pubmed/24884683
http://dx.doi.org/10.1186/1423-0127-21-41

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