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Synthesis and activity of three new trinuclear platinums with cis-geometry for terminal metal centres

BACKGROUND: As compared to cisplatin, trinuclear platinum compounds such as BBR3464 and DH6Cl have an altered spectrum of activity possibly because they form long-range adducts with DNA as against mainly intrastrand 1,2-bifunctional adducts formed by cisplatin and its analogues. Because of the labil...

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Detalles Bibliográficos
Autores principales:	Hamad, Shahnaz A, Beale, Philip, Yu, Jun Q, Huq, Fazlul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022405/ https://www.ncbi.nlm.nih.gov/pubmed/24884683 http://dx.doi.org/10.1186/1423-0127-21-41

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