Characterization of a new mouse p53 variant: loss-of-function and gain-of-function

BACKGROUND: p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation or inactivating interactions with viral or cellular proteins. The uncertainties around the link between p53 status, therapeutic response, and outcome in cancer suggest that addit...

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Detalles Bibliográficos
Autores principales: Chan, James Yi-Hsin, Chen, Ying-Chuan, Liu, Shu-Ting, Chou, Wei-Yuan, Ho, Ching-Liang, Huang, Shih-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022406/
https://www.ncbi.nlm.nih.gov/pubmed/24884657
http://dx.doi.org/10.1186/1423-0127-21-40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022406/
https://www.ncbi.nlm.nih.gov/pubmed/24884657
http://dx.doi.org/10.1186/1423-0127-21-40

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